Cancer Content

Outside-In Signaling Shows a Route Into Cancer Cells

Andy Fell — February 04, 2025 - 9:08am

A new study shows how an anticancer drug triggers an “outside in” signal that gets it sucked into a cancer cell. The work, published Jan. 29 in Nature Communications, reveals a new signaling mechanism that could be exploited for delivering other drugs.

Many malignant cancers overexpress a protein called P-cadherin, which is embedded in the cell membrane. Because cancer cells have a lot of P-cadherin sticking out of their surface, the protein has been targeted for drug development.

When Should You Neuter or Spay Your Dog?

Amy M Quinton — May 28, 2024 - 9:30am

A �鶹��ý study updates guidelines for when you should neuter or spay your dog to prevent increased risk of certain cancers or joint disorders.

Researchers Identify Protein Linked to Metastasis in Pancreatic Cancer

Andy Fell — February 02, 2024 - 9:00am

Pancreatic cancer is the No. 3 cause of cancer-related deaths in the United States, and only 12% of patients survive five years after being diagnosed. Severe pancreatic cancer is associated with metastasis, and it is this spread of secondary tumors that usually causes death, but little is known about the molecular mechanisms that drive metastasis.

Experiments in Yeast Hint at Possible Origins of Cancer and Autism

Andy Fell — October 24, 2023 - 4:51pm

Cancer often starts with the reshuffling of DNA—akin to scrambling the pages of a dictionary. Exactly how this happens has long been a mystery. But researchers in the �鶹��ý College of Biological Sciences have now arrived at one promising explanation.

Can Golden Retrievers Live Longer?

Amy M Quinton — October 19, 2023 - 8:00am

Learn how �鶹��ý researchers have found a gene associated with longevity in golden retrievers, a dog breed with a 65% chance of dying of cancer.

Engineered Bone Marrow Shows Promise for Developing Cancer Treatment

Andy Fell — September 15, 2023 - 3:15pm

The development of engineered bone marrow is revolutionizing research and treatment for osteosarcoma, the most common malignant bone cancer in children.

‘Unfold’ Podcast Episode 3: ‘How Dogs Could Help Doctors Find the Next Cancer Treatment’

Amy M Quinton — October 18, 2022 - 11:24am

�鶹��ý doctors and veterinarians are teaming up to help fight cancer in both dogs and humans.

Treating Cancer by Sticking Cells in Place

Andy Fell — August 03, 2022 - 12:00pm

Future treatments for advanced cancer could work by sticking cancer cells in place and preventing their spread around the body. A new study by researchers at the University of California, Davis, and the University of Washington shows how an antibody strengthens bonds between cells. The work is published Aug. 3 in Proceedings of the National Academy of Sciences.

Study Highlights Molecular Targets for Breast Cancer Treatment

Andy Fell — November 22, 2021 - 3:38pm

It’s estimated that over 281,000 women in the U.S. will be diagnosed with breast cancer this year, according to the National Cancer Institute. And about one in seven women will receive a breast cancer diagnosis in their lifetime.

For those with breast cancer gene 2 (BRCA2) mutations, the risk of developing breast cancer is much higher. Between 45 and 69 percent of those with this genetic mutation will develop breast cancer by 70 to 80 years of age.

Anti-inflammation Drug Combination May Help Pancreatic and Liver Cancer Patients

Andy Fell — September 28, 2021 - 10:54am

A drug candidate discovered and developed decades ago in the laboratory of �鶹��ý distinguished professor Bruce Hammock may help control the body’s raging and often deadly inflammatory response to chemotherapy treatments, especially for pancreatic and liver cancer patients.

The research team, based in the laboratories of Dipak Panigrahy at Harvard Medical School and Hammock, announced the findings in Proceedings of the National Academy of Sciences (PNAS) this week.