Outside-In Signaling Shows a Route Into Cancer Cells

Andy Fell — February 04, 2025 - 9:08am

A new study shows how an anticancer drug triggers an “outside in” signal that gets it sucked into a cancer cell. The work, published Jan. 29 in Nature Communications, reveals a new signaling mechanism that could be exploited for delivering other drugs.

Many malignant cancers overexpress a protein called P-cadherin, which is embedded in the cell membrane. Because cancer cells have a lot of P-cadherin sticking out of their surface, the protein has been targeted for drug development.

P-cadherin Content

Outside-In Signaling Shows a Route Into Cancer Cells